Pathologic Determinants of Survival After Resection of T3N0 (Stage IIA) Colorectal Cancer: Proposal for a New Prognostic Model

• Published in: Diseases of the colon & rectum Vol. 50; no. 9; pp. 1332 - 1341
• Main Authors: Cianchi, Fabio, Messerini, Luca, Comin, Camilla Eva, Boddi, Vieri, Perna, Federico, Perigli, Giuliano, Cortesini, Camillo
• Format: Journal Article
• Language: English
• Published: Secaucus, NJ The ASCRS 01.09.2007; Springer; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - metabolism; Colectomy; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Italy - epidemiology; Keratin-20 - metabolism; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Neoplasm Staging; Pelvis; Prognosis; Retrospective Studies; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Survival Rate - trends; Tumors; Italy; Human; Immunohistochemistry; Postoperative; Rectal disease; Prognosis; Lymph node; Colorectal cancer; Surgical resection; Malignant tumor; Metastasis; Survival; Lymph node micrometastases; Colonic disease; Anatomic pathology; Treatment; Pathologic parameters; Surgery; Micrometastasis; Digestive diseases; Intestinal disease; Models
• ISSN: 0012-3706; 1530-0358
• DOI: 10.1007/s10350-007-0222-9

PURPOSE: METHODS: RESULTS:Multivariate analysis identified tumor growth pattern (expanding or infiltrating; P = 0.01) and extent of tumor spread beyond muscularis propria (≤5 mm or >5 mm; P = 0.04) as the only factors having independent prognostic value. The combination of these two easily determined parameters allowed us to identify two groups of patients at low risk or high risk of tumor recurrence. The eight-year survival rates were 83.3 and 53.4 percent for the two groups, respectively. The high-risk group comprised those patients with infiltrating tumors and extramural tumor spread > 5 mm. CONCLUSIONS: