Recent progress in the development of coumarin derivatives as potent anti-HIV agents

• Published in: Medicinal research reviews Vol. 23; no. 3; pp. 322 - 345
• Main Authors: Yu, Donglei, Suzuki, Madoka, Xie, Lan, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.05.2003
• Subjects: Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; anti-HIV coumarins; calanolides; Coumarins - chemistry; Coumarins - pharmacology; DCK analogs; Drug Design; HIV - drug effects; HIV - enzymology; Humans; inophyllums; khellactone; Solubility; Structure-Activity Relationship; tetracyclic dipyranocoumarins
• ISSN: 0198-6325; 1098-1128
• DOI: 10.1002/med.10034

Numerous plant‐derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure–activity relationship studies of potent anti‐HIV coumarin derivatives. A dicamphanoyl‐khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively. © 2003 Wiley Periodicals, Inc. Med Res Rev, 23, No. 3, 322‐345, 2003