Vitamin D and the skin

• Published in: Journal of dermatology Vol. 30; no. 6; p. 429
• Main Authors: Kira, Masahiro, Kobayashi, Teruaki, Yoshikawa, Kunihiko
• Format: Journal Article
• Language: English
• Published: England 01.06.2003
• Subjects: Forecasting; Humans; Psoriasis - drug therapy; Skin - drug effects; Skin Aging - drug effects; Vitamin D - analogs & derivatives; Vitamin D - pharmacology; Vitamin D - therapeutic use
• ISSN: 0385-2407
• DOI: 10.1111/j.1346-8138.2003.tb00412.x

Vitamin D was originally discovered as a factor that regulates calcium and bone metabolism. Recent advances in investigation have shown that vitamin D also functions as a regulator of cellular growth and differentiation in various tissues. The skin is not an exception from such effects of vitamin D; it is regarded as a site of its activation and action. Evidence has accumulated showing that the active form of vitamin D and its analogs suppress growth and stimulate the terminal differentiation of keratinocytes. In psoriatic lesions, epidermal keratinocytes exhibit hyper-proliferation and impaired differentiation triggered by inflammation. Therefore, it is quite reasonable that vitamin D is effective on psoriasis. Indeed, within the past decade, analogs of vitamin D3 have been used as topical therapy for psoriasis. In this review, we summarize the fundamental features of vitamin D and the development of vitamin D therapy for psoriasis. Clinical application to other skin diseases and the future of vitamin D therapy in dermatology are also discussed.