Combination therapy in the treatment of hypertension

Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive ag...

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Bibliographic Details
Published inDrugs in Context Vol. 7; p. 212531
Main Authors Guerrero-García, Carolina, Rubio-Guerra, Alberto Francisco
Format Journal Article
LanguageEnglish
Published England BioExcel Publishing Ltd 06.06.2018
Subjects
antihypertensive drugs
cardiovascular disease
combination therapy
hypertension
Review
therapeutic goals
antihypertensive drugs
cardiovascular disease
combination therapy
hypertension
therapeutic goals
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Summary:Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals - recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk. In addition, approximately 25% of patients will require three antihypertensive agents to achieve the therapeutic targets. In this review, we analyse the latest information available regarding the treatment of hypertension with combination therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1745-1981
1740-4398
1740-4398
DOI:10.7573/dic.212531