Regulation of mRNA stability in the nervous system and beyond

• Published in: Journal of neuroscience research Vol. 66; no. 3; pp. 311 - 316
• Main Author: Malter, James S.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.11.2001
• Subjects: Alzheimer's disease; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; Gene Expression Regulation - physiology; Genes, Regulator - physiology; Humans; HuR; mRNA; mRNA binding proteins; mRNA decay; myelin; Myelin Basic Protein - biosynthesis; Myelin Basic Protein - genetics; Nervous System - growth & development; Nervous System - metabolism; Protein Biosynthesis - physiology; RNA Processing, Post-Transcriptional - physiology; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism
• ISSN: 0360-4012; 1097-4547
• DOI: 10.1002/jnr.10021

The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence‐specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation. J. Neurosci. Res. 66:311–316, 2001. © 2001 Wiley‐Liss, Inc.