Dose Field Shaping and Biological Effectiveness of the Effect of Pulsed Electron Accelerator Novac-11 on Mammalian Cells

• Published in: Bulletin of experimental biology and medicine Vol. 172; no. 5; pp. 558 - 560
• Main Authors: Koryakina, E. V., Lychagin, A. A., Potetnya, V. I., Troshinа, M. V., Saburov, V. O., Moiseev, A. S., Koryakin, S. N., Ivanov, S. A., Shegai, P. V., Kaprin, A. D.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2022; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Biophysics and Biochemistry; Cell Biology; Cell survival; Cells; Electrons; Fibroblasts; Internal Medicine; Laboratory Medicine; Mammalian cells; Neoplasia; Pathology; Radiation; Radiation therapy; Radiotherapy; Technology application; Tumors; γ Radiation; Novac-11; chemical FBX and Fricke dosimeters; cell survival; electrons; V-79 cells
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05432-3

The development of technologies for using the Novac-11 pulsed electron accelerator in radiation therapy of animals with spontaneous neoplasms requires dosimetric and radiobiological studies. The studies were performed on cultured Chinese hamster V-79 fibroblasts after irradiation with 10 MeV electrons in a dose range up to 12 Gy and 60 Co γ-radiation. Chemical dosimeters FBX and Fricke were used as additional test-systems. The depth dose curves were measured and the maximum dose depth of the electron beam was determined in tissue-equivalent phantoms. Cell survival and the data of chemical dosimetric systems showed that the effects of electron irradiation did not differ from that of 60 Co γ-radiation. It was concluded that the use of Novac-11 in the therapy of animals with spontaneous neoplasms is advisable.