Genetic Markers of Predisposition to Increased Anxiety

• Published in: Bulletin of experimental biology and medicine Vol. 146; no. 6; pp. 774 - 778
• Main Authors: Kulikova, M. A, Trushkin, E. V, Timofeeva, M. A, Shlepzova, V. A, Schegolkova, J. V, Maluchenko, N. V, Tonevitsky, A. G
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.12.2008; Springer US; Springer Nature B.V
• Subjects: Adolescent; Adult; anxiety; Anxiety - genetics; Biomedical and Life Sciences; Biomedicine; Catechol O-Methyltransferase - genetics; Cell Biology; dopamine; Dopamine - metabolism; Dopamine Plasma Membrane Transport Proteins - genetics; dopamine receptor DRD2; dopamine transporter DAT; Female; Genetic Markers; Genetic Predisposition to Disease - genetics; Genetics; Genotype; Humans; Internal Medicine; Laboratory Medicine; Male; Models, Biological; Models, Theoretical; Pathology; Receptors, Dopamine D2 - genetics; striatum; Young Adult; dopamine receptor DRD2; anxiety; striatum; dopamine; dopamine transporter DAT
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0373-x

Associations of functional polymorphism in genes of dopamine receptor DRD2, dopamine transporter DAT, and dopamine degrading enzyme COMT with variations in anxiety sensitivity threshold were studied. On the basis of genetic and psychological analysis, an attempt was undertaken to evaluate the relationship of DRD2, DAT and COMT genotypes with values obtained using different anxiety scales. It was found that carriers of VA1+9+ genotype exhibit increased anxiety and significantly differed from individuals with other genotypes. The results were illustrated with model of dopamine diffusion in the extracellular space of the striatum in carriers of different genotypes.