Synthesis and In Vivo Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants

A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ±...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 53; no. 5; pp. 419 - 422
Main Authors Bang, Nguyen Cong, Abyshev, A. Z., Ivkin, D. Yu
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2019
Springer
Subjects
Anti-arrhythmia drugs
Anticoagulants (Medicine)
Blood
Medical examination
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Prothrombin
Search for New Drugs
Thrombin
prothrombin time
coumarins
phenolic acids
anticoagulant activity
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Summary:A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ± 0.56 sec) and 4b (13.10 ± 3.56 sec) were the most active and comparable to the reference drug warfarin (7.97 ± 1.93 sec).
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02013-z