Trypanosoma cruzi: Biological characterization of lineages I and II supports the predominance of lineage I in Colombia
The causes of the particular distribution of both Trypanosoma cruzi lineages throughout the American continent remain unknown. In Colombia, T. cruzi I is the predominant group in both domestic and sylvatic cycles. Here, we present the biological characterization of T. cruzi parasites belonging to bo...
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Published in | Experimental parasitology Vol. 121; no. 1; pp. 83 - 91 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
2009
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The causes of the particular distribution of both
Trypanosoma cruzi lineages throughout the American continent remain unknown. In Colombia,
T. cruzi I is the predominant group in both domestic and sylvatic cycles. Here, we present the biological characterization of
T. cruzi parasites belonging to both
T. cruzi I and
T. cruzi IIb groups. Our results show the inability of the
T. cruzi IIb clones to infect mammalian cells, produce trypomastigotes and replicate in
Rhodnius prolixus, the main vector species in this country. Moreover, this result was confirmed when other species from the same genus, such as
R. pallescens and
R. robustus, were infected with the same TcIIb clone and its parental strain, while the infection in other genera such as
Triatoma and
Panstrongylus was successful. Furthermore, the growth kinetics and duplication time
in vitro suggest that the high prevalence of
T. cruzi I in Colombia results from more successful interactions between parasite lineage, vector, and host species. This type of study may help to understand the factors influencing the particular epidemiological patterns of Chagas disease transmission in different endemic regions. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0014-4894 1090-2449 |
DOI: | 10.1016/j.exppara.2008.10.002 |