A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood
Introduction: Blood levels of uremic toxin, asymmetric dimethylarginine (ADMA), are strongly associated with mortality in sepsis, renal failure, and cardiovascular and renal disease patients. Methods: An extracorporeal approach to reduce pathological ADMA was developed. The dimethylarginine dimethyl...
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Published in | Blood purification Vol. 51; no. 11; pp. 889 - 898 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Basel, Switzerland
01.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Introduction: Blood levels of uremic toxin, asymmetric dimethylarginine (ADMA), are strongly associated with mortality in sepsis, renal failure, and cardiovascular and renal disease patients. Methods: An extracorporeal approach to reduce pathological ADMA was developed. The dimethylarginine dimethylaminohydrolase (DDAH) was immobilized on agarose beads to prepare a cartridge. The efficacy of cartridge for ADMA lowering in blood was investigated. Results: The DDAH beads and cartridge reduced ADMA from solution or plasma. The magnitude of ADMA removal was dependent on the quantity of DDAH linked to the beads and the flow rate. When tested in association with plasmapheresis, the DDAH-cartridge was highly effective in ADMA removal from the blood and improved the arginine/ADMA ratio in a pig model. Conclusion: A new, safe, and effective extracorporeal approach to lower ADMA was developed which may have application in improving outcomes in patients with vascular complications and risk of mortality associated with high ADMA. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Participated in research design: Young Lee, Sarah Steinbach, Jaipal Singh, David Basile Performed data analysis: Young Lee Conducted experiments: Young Lee, Sarah Steinbach Contributed to writing: Young Lee, Sarah Steinbach, Jaipal Singh Author Contributions |
ISSN: | 0253-5068 1421-9735 1421-9735 |
DOI: | 10.1159/000522294 |