Vertebrate distribution of corticosteroid-binding globulin and some endocrine effects on concentration

Corticosteroid-binding globulin was measured by means of a gel-filtration technic in 131 species representing all of the vertebrate classes. Evidence for the presence of a binding protein was found in every instance. The concentration varied widely but consistencies within taxonomic groupings were o...

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Bibliographic Details
Published inSteroids Vol. 5; no. 6; pp. 827 - 841
Main Authors Seal, U.S., Doe, R.P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.1965
Subjects
Animals
Blood Chemical Analysis
Chromatography, Gel
Corticosterone
Humans
Hydrocortisone
Metabolism
Old Medline
Transcortin
Vertebrates
CORTICOSTERONE
METABOLISM
BLOOD CHEMICAL ANALYSIS
EXPERIMENTAL LAB STUDY
VERTEBRATES
GEL FILTRATION
TRANSCORTIN
HYDROCORTISONE
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Summary:Corticosteroid-binding globulin was measured by means of a gel-filtration technic in 131 species representing all of the vertebrate classes. Evidence for the presence of a binding protein was found in every instance. The concentration varied widely but consistencies within taxonomic groupings were observed. Estimates of the relative affinity for cortisol and corticosterone revealed no consistent relationship with the predominant circulating corticosteroid. Striking differences in affinity were found in the porcupine fish and iguana which would make these species particularly useful for binding site studies. Studies of endocrine-deficient and endocrine-treated animals demonstrated changes in CBG concentration in several species; however, no single response occurred in all species.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(65)90174-1