Inferior vena caval hemodynamics quantified in vivo at rest and during cycling exercise using magnetic resonance imaging
Departments of 1 Mechanical Engineering, 2 Radiology, and 3 Surgery, Stanford University, Stanford, California 94305-3030 Compared with the abdominal aorta, the hemodynamic environment in the inferior vena cava (IVC) is not well described. With the use of cine phase-contrast magnetic resonance im...
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Published in | American journal of physiology. Heart and circulatory physiology Vol. 284; no. 4; pp. H1161 - H1167 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.04.2003
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Subjects | |
Online Access | Get full text |
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Summary: | Departments of 1 Mechanical Engineering,
2 Radiology, and 3 Surgery, Stanford
University, Stanford, California 94305-3030
Compared with
the abdominal aorta, the hemodynamic environment in the inferior vena
cava (IVC) is not well described. With the use of cine phase-contrast
magnetic resonance imaging (MRI) and a custom MRI-compatible cycle in
an open magnet, we quantified mean blood flow rate, wall shear stress,
and cross-sectional lumen area in 11 young normal subjects at the
supraceliac and infrarenal levels of the aorta and IVC at rest and
during dynamic cycling exercise. Similar to the aorta, the IVC
experienced significant increases in blood flow and wall shear stress
as a result of exercise, with greater increases in the infrarenal level
compared with the supraceliac level. At the infrarenal level during
resting conditions, the IVC experienced higher mean flow rate than the
aorta (1.2 ± 0.5 vs. 0.9 ± 0.4 l/min, P < 0.01) and higher mean wall shear stress than the aorta (2.0 ± 0.6 vs. 1.3 ± 0.6 dyn/cm 2 , P < 0.005).
During exercise, wall shear stress remained higher in the IVC compared
with the aorta, although not significantly. It was also observed that,
whereas the aorta tapers inferiorly, the IVC tapers superiorly from the
infrarenal to the supraceliac location. The hemodynamic and anatomic
data of the IVC acquired in this study add to our understanding of the
venous circulation and may be useful in a clinical setting.
blood flow rate; wall shear stress; lumen area; functional flow
imaging |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0363-6135 1522-1539 |
DOI: | 10.1152/ajpheart.00641.2002 |