Cognitive Performance Effects of Bilastine 20 mg During 6 Hours at 8000 ft Cabin Altitude

• Published in: Aerospace medicine and human performance Vol. 87; no. 7; p. 622
• Main Authors: Valk, Pierre J L, Simons, Ries, Jetten, Andrea M, Valiente, Román, Labeaga, Luis
• Format: Journal Article
• Language: English
• Published: United States 01.07.2016
• Subjects: Altitude; Benzimidazoles - adverse effects; Benzimidazoles - pharmacology; Cognition - drug effects; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating - adverse effects; Histamine H1 Antagonists, Non-Sedating - pharmacology; Humans; Male; Piperidines - adverse effects; Piperidines - pharmacology; Psychomotor Performance - drug effects; Sleep Stages
• ISSN: 2375-6314
• DOI: 10.3357/AMHP.4522.2016

Bilastine is a new oral, second generation antihistamine used in the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. It is considered a nonsedating antihistamine and might be recommended for use in pilots, pending research on the effects on flying-related performance under hypobaric conditions that prevail in an airliner. We assessed the effects of a single dose of bilastine 20 mg on alertness and complex task performance of healthy volunteers in a hypobaric chamber at 75.2 kPa (8000 ft/2438 m cabin altitude). In a randomized, double-blind, crossover study, 24 volunteers received a single dose of bilastine 20 mg, hydroxyzine 50 mg (active control), and placebo. Using the Vigilance and Tracking Task, Multi-Attribute Task Battery, and Stanford Sleepiness Scale, assessments were made before and up to 6 h after intake of the study medication. Bilastine 20 mg had no impairing effects on sleepiness levels, vigilance, or complex task performance for up to 6 h post-dose. Hydroxyzine 50 mg (active control) was associated with significant sleepiness and impaired performance across this time period, confirming the sensitivity of the tests. Bilastine 20 mg did not cause sleepiness or impaired performance on tasks related to flying. It is anticipated that a single dose of bilastine 20 mg will not affect flying performance. Bilastine may provide a safe therapeutic alternative for pilots suffering from allergic rhinitis or urticaria. Our findings might also have implications for the treatment of allergic disorders of personnel involved in other safety-sensitive jobs. Valk PJL, Simons R, Jetten AM, Valiente R, Labeaga L. Cognitive performance effects of bilastine 20 mg during 6 hours at 8000 ft cabin altitude. Aerosp Med Hum Perform. 2016; 87(7):622-627.