Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes

• Published in: Biochimie Vol. 85; no. 12; pp. 1213 - 1218
• Main Authors: Tordjman, Joan, Khazen, Wael, Antoine, Bénédicte, Chauvet, Geneviève, Quette, Joelle, Fouque, Françoise, Beale, Elmus G., Benelli, Chantal, Forest, Claude
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.12.2003
• Subjects: Animals; Diabetes Mellitus, Type 2 - enzymology; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Fatty Acids - pharmacology; Gene Expression Regulation, Enzymologic - drug effects; Glitazones; Glucocorticoids; Glycerol - metabolism; Peroxisome proliferator activated receptors; Phosphoenolpyruvate Carboxykinase (GTP) - genetics; Phosphoenolpyruvate Carboxykinase (GTP) - metabolism; Re-esterification; Thiazolidinediones - pharmacology; Transcription factors; Tretinoin - pharmacology; Transcription factors; DR1; RAR; Re-esterification; Glucocorticoids; G3P; Glitazones; GRU; WAT; RXR; PEPCK-C; RA; Peroxisome proliferator activated receptors; LCFA; PPAR; NEFA; PPRE; CAT; COUP-TF; GRE; DHA; TZD
• ISSN: 0300-9084; 1638-6183
• DOI: 10.1016/j.biochi.2003.11.010

Recent studies brought adipocyte glyceroneogenesis back to the fore as an important pathway in fatty acid homeostasis and underlined the key role played by cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for disregulation of this pathway in type 2 diabetes.