Mesenchymal Stem/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy

Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the development of cell therapeutics in regenerative medicine. Featuring immunomodulatory potential as well as secreting a variety of trophic factors, MSCs showed remarkable therapeutic effects in numerous preclinical dise...

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Bibliographic Details
Published inTransfusion medicine and hemotherapy Vol. 43; no. 4; pp. 256 - 267
Main Authors Schäfer, Richard, Spohn, Gabriele, Baer, Patrick C.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger GmbH 01.07.2016
Subjects
Review
Review Article
Bone marrow
Stem cell transplantation
Stroke
Stem cells
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Summary:Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the development of cell therapeutics in regenerative medicine. Featuring immunomodulatory potential as well as secreting a variety of trophic factors, MSCs showed remarkable therapeutic effects in numerous preclinical disease models. However, sustainable translation of MSC therapies to the clinic is hampered by heterogeneity of MSCs and non-standardized in vitro culture technologies. Moreover, potent MSC therapeutics require MSCs with maximum regenerative capacity. There is growing evidence that in vitro preconditioning strategies of MSCs can optimize their therapeutic potential. In the following we will discuss achievements and challenges of the development of MSC therapies in regenerative medicine highlighting specific in vitro preconditioning strategies prior to cell transplantation to increase their therapeutic efficacy.
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ISSN:1660-3796
1660-3818
DOI:10.1159/000447458