Neural correlates of prickle sensation: a percept-related fMRI study

The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain qua...

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Bibliographic Details
Published inNature neuroscience Vol. 5; no. 11; pp. 1121 - 1122
Main Authors Davis, K.D, Pope, G.E, Crawley, A.P, Mikulis, D.J
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.11.2002
Subjects
Brain - physiology
Causes of
Cerebral cortex
Cold Temperature
Diabetic neuropathy
Humans
Magnetic Resonance Imaging
Medical examination
Methods
Pain
Pain - physiopathology
Physiological aspects
Sensation - physiology
Touch - physiology
United States
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Summary:The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we used a new functional magnetic resonance imaging (fMRI) method to identify time-locked responses to prickle sensations that were evoked by noxious cold stimuli. With percept-related fMRI, we identified prickle-related brain activations in the anterior cingulate cortex (ACC), insula, secondary somatosensory cortex (S2), prefrontal cortex (PFC), premotor cortex (PMC), caudate nucleus and dorsomedial thalamus, indicating that multiple pain, sensory and motor areas act together to produce the prickle sensation.
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ISSN:1097-6256
1546-1726
DOI:10.1038/nn955