Neuroendocrine control of feeding behavior and psychomotor activity by pituitary adenylate cyclase-activating polypeptide (PACAP) in vertebrates

Summary Food intake is a fundamental for animals to surviving and keeping offspring. The hypothalamic region of the brain and the brain stem in vertebrates are a center that plays an important role in the control of feeding and its related behaviors including locomotor and psychomotor activities. Pi...

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Published inObesity research & clinical practice Vol. 7; no. 1; pp. e1 - e7
Main Authors Matsuda, Kouhei, Azuma, Morio, Maruyama, Keisuke, Shioda, Seiji
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2013
Subjects
Animals
Appetite Regulation
Brain - metabolism
Eating
Emotions - physiology
Endocrinology & Metabolism
Feeding Behavior - physiology
Humans
Internal Medicine
Motor Activity - physiology
Neurosecretory Systems
Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism
Satiation - physiology
Vertebrates
Vertebrates
Feeding regulation
PACAP
Emotional control
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Summary:Summary Food intake is a fundamental for animals to surviving and keeping offspring. The hypothalamic region of the brain and the brain stem in vertebrates are a center that plays an important role in the control of feeding and its related behaviors including locomotor and psychomotor activities. Pituitary adenylate cyclase-activating polypeptide (PACAP) has firstly been identified as a hypophysiotropic hormone involved in adenohypophyseal hormone release, and subsequently has been considered as a neuropeptide exerting multifunctional roles in the central and peripheral nervous systems and several tissues in vertebrates. For example, PACAP is involved in the neuroendocrine control of food intake and acts as an anorexigenic peptide to regulate satiety. Recent works on animal models such as rodents and goldfish which are both excellent animal models for investigating the neuroendocrinological roles of PACAP have been extensively examined and considerable information has been accumulated. In addition, psychophysiological effects of PACAP on emotional behavior have recently been found. Therefore, this review article provides an overview of the neuroendocrine regulation of feeding behavior and psyphysiological activity by PACAP in vertebrates.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1871-403X
1878-0318
DOI:10.1016/j.orcp.2012.10.002