Functional magnetic resonance imaging in an animal model of pancreatic cancer

AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model.METHODS: VX2 tumors were implanted in pancreata of 6 rabbits....

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Published inWorld journal of gastroenterology : WJG Vol. 16; no. 26; pp. 3292 - 3298
Main Authors Lewandowski, Robert J, Eifler, Aaron C, Bentrem, David J, Chung, Johnathan C, Wang, Dingxin, Woloschak, Gayle E, Yang, Guang-Yu, Ryu, Robert, Salem, Riad, Larson, Andrew-C, Omary, Reed-A
Format Journal Article
LanguageEnglish
Published United States Baishideng 14.07.2010
Subjects
Angiography, Digital Subtraction
Animals
Brief
Catheterization
Disease Models, Animal
Magnetic Resonance Imaging - methods
Necrosis
Pancreatic Neoplasms - blood supply
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - pathology
Rabbits
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Summary:AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model.METHODS: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T M...
Bibliography:Functional magnetic resonance imaging
Animal model
14-1219/R
Animal model; Functional magnetic resonance imaging; Pancreatic cancer
Pancreatic cancer
R735.9
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
Telephone: +1-312-6959121 Fax: +1-312-9265991
Correspondence to: Robert J Lewandowski, MD, Assistant Professor, Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Suite 800, Chicago, IL 60611, United States. r-lewandowski@northwestern.edu
Author contributions: Larson AC, Omary RA and Lewandowski RJ designed the research; Bentrem DJ, Woloschak GE and Yang GY contributed the animal model; Chung JC, Wang D and Larson AC performed the imaging; Ryu R, Salem R and Omary RA performed catheterization of rabbits; Eifler AC analyzed the data; Lewandowski RJ and Eifler AC wrote the manuscript.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i26.3292