Protective effect of periplaneta americana extract on intestinal mucosal barrier function in patients with sepsis

• Published in: Journal of traditional Chinese medicine Vol. 33; no. 1; pp. 70 - 73
• Main Authors: Zhang, Hongwei, Wei, Liyou, Zhang, Zhenyu, Liu, Shuzheng, Zhao, Gang, Zhang, Jing, Hu, Yanling
• Format: Journal Article
• Language: English
• Published: China 01.02.2013
• Subjects: Adult; Aged; Animals; APACHE; Biological Factors - administration & dosage; Biological Factors - isolation & purification; Female; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - physiopathology; Male; Middle Aged; Periplaneta - chemistry; Protective Agents - administration & dosage; Protective Agents - isolation & purification; Sepsis - drug therapy; Sepsis - mortality; Sepsis - physiopathology; Sepsis - prevention & control; Young Adult; 保护作用; 屏障功能; 患者; 提取物; 美洲大蠊; 肠黏膜; 脓毒症
• ISSN: 0255-2922
• DOI: 10.1016/S0254-6272(13)60103-X

OBJECTIVE： To investigate the effect of the periplaneta americana extract on the intestinal mucosal barrier and prognostic implications in patients with sepsis. METHODS： Sixty and six patients with sepsis were assigned randomly to treatment group （32 cases） and control group （32 cases）. The extractfrom periplaneta americana plus conventional medication for sepsis was administered to the treatment group, while the control group only received conventional treatment. The gastrointestinal function scores and acute physiology and chronic health evaluation II （APACHE 11 ） scores of all subjects were documented at baseline, at days 1, 3 and 7 after treatment respectively and their blood endotoxin was tested at the same time points as well. The incidence of death was recorded for both groups throughout the trial. RESULTS： At days 3 and 7 after treatment, gastrointestinal function score, APACHE II, and endotoxin level in treatment group wasbetter than that in con- trol group and the difference between them was significant （both P〈0~05）. Although the incidence of death in treatment group was less than that in control group, the difference between the two groups was not significant （P〉 0.05）. CONCLUSION： The extract of periplaneta ameri- cana had protective effect on intestinal mucosal barrier and could improve the condition and prog- nosis in patients with sepsis.