Effect of sodium bicarbonate preloading on ischemic renal failure

Rats pretreated with sodium bicarbonate were functionally protected from the damage of bilateral renal artery occlusion. The rise in serum creatinine (day 1 minus day 0) during the first 24 h after ischemia was 2.88 +/- 0.28 mg% in the bicarbonate-loaded animals versus 3.90 +/- 0.26 mg% in their mat...

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Bibliographic Details
Published inNephron (2015) Vol. 44; no. 1; p. 70
Main Author Atkins, J L
Format Journal Article
LanguageEnglish
Published Switzerland 1986
Subjects
Acetazolamide - therapeutic use
Acute Kidney Injury - prevention & control
Animals
Bicarbonates - therapeutic use
Creatinine - blood
Diuresis - drug effects
Hydrogen-Ion Concentration
Ischemia - blood
Ischemia - complications
Kidney - blood supply
Male
Osmolar Concentration
Rats
Rats, Inbred Strains
Sodium - therapeutic use
Sodium Bicarbonate
Urine - physiology
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Summary:Rats pretreated with sodium bicarbonate were functionally protected from the damage of bilateral renal artery occlusion. The rise in serum creatinine (day 1 minus day 0) during the first 24 h after ischemia was 2.88 +/- 0.28 mg% in the bicarbonate-loaded animals versus 3.90 +/- 0.26 mg% in their matched controls (p less than or equal to 0.01). Pretreatment with acetazolamide produced a similar alkaline urine as the bicarbonate loading (pH 8.3 vs. 7.0 in controls) and a similar degree of protection (delta creatinine 2.85 +/- 0.41 vs. 4.23 +/- 0.26 mg%; p less than or equal to 0.01). A direct effect of sodium loading was excluded by comparing NH4HCO3 with NaHCO3 loading and observing no difference in delta creatinine levels after ischemia (3.39 +/- 0.69 vs. 3.20 +/- 0.61 mg%). These data indicate that NaHCO3 protects in this model of acute renal failure and further suggest that the mechanism of protection is not related to either systemic alkalosis or sodium loading.
ISSN:1660-8151
DOI:10.1159/000183915