Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency

All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent...

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Bibliographic Details
Published inPathogens (Basel) Vol. 6; no. 3; p. 28
Main Authors Thellman, Nikki M, Triezenberg, Steven J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.06.2017
MDPI
Subjects
Activation
Cell culture
Cell lines
Culture techniques
Feasibility studies
Herpes simplex
Herpes viruses
Infections
Latency
Latent infection
Review
Viruses
HSV-1
cell culture
lytic infection
neuron
quiescent infection
latent infection
HSV-2
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Summary:All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent infection provide valuable insight on the host processes regulating viral establishment and maintenance of latency. More robust and rapid than infections in live animal studies, advancements in neuronal culture techniques have made the systematic analysis of viral reactivation mechanisms feasible. Only recently have human neuronal cell lines been available, but models in the natural host cell are a critical addition to the currently available models.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens6030028