The therapeutic potential of exosomes derived from different cell sources in liver diseases

Exosomes are small nanovesicles with a size of approximately 40-120 nm that are secreted from cells. They are involved in the regulation of cell homeostasis and mediate intercellular communication. In addition, they carry proteins, nucleic acids, and lipids that regulate the biological activity of r...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 322; no. 4; pp. G397 - G404
Main Authors Pan, Yun, Tan, Wei-Feng, Yang, Mu-Qing, Li, Ji-Yu, Geller, David A
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.04.2022
Subjects
Biological activity
Carcinoma, Hepatocellular - metabolism
Cell interactions
Exosomes
Exosomes - metabolism
Fibrosis
Hepatocellular carcinoma
Hepatocytes
Homeostasis
Humans
Ischemia
Lipids
Liver Cirrhosis - metabolism
Liver Cirrhosis - therapy
Liver diseases
Liver Neoplasms - metabolism
Liver Neoplasms - therapy
Reperfusion
Review
role
liver disease
therapeutic potential
exosomes
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Summary:Exosomes are small nanovesicles with a size of approximately 40-120 nm that are secreted from cells. They are involved in the regulation of cell homeostasis and mediate intercellular communication. In addition, they carry proteins, nucleic acids, and lipids that regulate the biological activity of receptor cells. Recent studies have shown that exosomes perform important functions in liver diseases. This review will focus on liver diseases (drug-induced liver injury, hepatic ischemia-reperfusion injury, liver fibrosis, acute liver failure, and hepatocellular carcinoma) and summarize the therapeutic potential of exosomes from different cell sources in liver disease.
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Y. Pan and W. Tan contributed equally to this work.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00054.2021