Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids

Human brain organoids are 3-dimensional cell aggregates that are generated from pluripotent stem cells and recapitulate features of the early developing human brain. Brain organoids mainly consist of cells from the neural lineage, such as neural progenitor cells, neurons, and astrocytes. However, cu...

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Published inBiological psychiatry (1969) Vol. 93; no. 7; pp. 616 - 621
Main Authors Wang, Meiyan, Gage, Fred H., Schafer, Simon T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2023
Subjects
Astrocytes
Brain
Brain organoids
Humans
Induced Pluripotent Stem Cells
Induced pluripotent stem cells (iPSCs)
Microglia
Neural Stem Cells
Neurons
Organoids
Pluripotent Stem Cells - physiology
Transplantation
Transplantation
Astrocytes
Brain organoids
Induced pluripotent stem cells (iPSCs)
Microglia
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Summary:Human brain organoids are 3-dimensional cell aggregates that are generated from pluripotent stem cells and recapitulate features of the early developing human brain. Brain organoids mainly consist of cells from the neural lineage, such as neural progenitor cells, neurons, and astrocytes. However, current brain organoid systems lack functional vasculature as well as other non-neuronal cells that are indispensable for oxygen and nutrient supply to the organoids, causing cell stress and formation of a necrotic center. Attempts to utilize intracerebral transplantation approaches have demonstrated successful vascularization of brain organoids and robust neurodifferentiation. In this review, we summarize recent progress and discuss ethical considerations in the field of brain organoid transplantation.
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ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2023.01.004