A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy

Abstract To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992–1994 when they we...

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Published inOpen forum infectious diseases Vol. 7; no. 6; p. ofaa206
Main Authors Chesnais, Cédric B, Bizet, Charlotte, Campillo, Jérémy T, Njamnshi, Wepnyu Y, Bopda, Jean, Nwane, Philippe, Pion, Sébastien D, Njamnshi, Alfred K, Boussinesq, Michel
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.06.2020
Subjects
Brief Report
Life Sciences
Microbiology and Parasitology
Parasitology
epilepsy
cohort
onchocerciasis
causal relationship
Africa
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Summary:Abstract To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992–1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992–1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1–7, 8–70, 71–200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill’s criteria for causality.
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ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa206