Internalization of cationic peptides: the road less (or more?) traveled

Facilitating the entry of molecules into mammalian cells is of great interest to fields as diverse as cell biology and drug delivery. The discovery of natural protein transduction domains and the development of artificial ones, including polyarginine, provides a means to achieve this goal. Here, we...

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Bibliographic Details
Published inCellular and molecular life sciences : CMLS Vol. 63; no. 16; pp. 1819 - 1822
Main Authors Fuchs, S M, Raines, R T
Format Journal Article
LanguageEnglish
Published Switzerland Springer Nature B.V 01.08.2006
Subjects
Animals
Biochemistry
Cations
Cell Membrane - metabolism
Cellular biology
Drug delivery systems
Endocytosis
Mammals
Models, Biological
Peptides
Peptides - metabolism
Protein Transport
Proteins
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Summary:Facilitating the entry of molecules into mammalian cells is of great interest to fields as diverse as cell biology and drug delivery. The discovery of natural protein transduction domains and the development of artificial ones, including polyarginine, provides a means to achieve this goal. Here, we comment on key chemical and biological aspects of cationic peptide internalization, including the physiological relevance of this process.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-2
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-006-6170-z