Daptomycin-Resistant, Methicillin-Resistant Staphylococcus aureus Bacteremia

• Published in: Clinical infectious diseases Vol. 40; no. 7; pp. 1058 - 1060
• Main Authors: Mangili, A., Bica, I., Snydman, D. R., Hamer, D. H.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.04.2005; University of Chicago Press; Oxford University Press
• Subjects: Anti-Bacterial Agents; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimicrobials; Bacteremia; Bacteremia - microbiology; Bacterial diseases; Bacterial sepsis; Biological and medical sciences; Blood; Brief Reports; Daptomycin - pharmacology; Drug resistance; Drug Resistance, Multiple, Bacterial; Human bacterial diseases; Humans; Infections; Infectious diseases; Lower extremity; Male; Medical sciences; Medical treatment; Methicillin Resistance; Methicillin resistant staphylococcus aureus; Middle Aged; Pathogens; Pharmacology. Drug treatments; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification; Human; Daptomycin; Cardiovascular disease; Thrombophlebitis; Bacteremia; Venous disease; Infection; Vascular disease; Resistance; Antibiotic; Treatment; Gram positive bacteria; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Portal vein; Antibacterial agent; Staphylococcal infection; Lipopeptide; Staphylococcus aureus
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1086/428616

We describe a patient who developed daptomycin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) during an episode of presumed septic thrombophlebitis of the portal vein. Although daptomycin is an alternative agent for treatment of drug-resistant gram-positive bacterial infections, development of resistance during prolonged use may occur with MRSA bacteremia from a persistent focus.