The Prospects for and Pathways toward a Vaccine for AIDS

ACQUIRED immunodeficiency syndrome (AIDS) is a severe disease of the immune system caused by a horizontally transmitted retrovirus. Although this virus has been given several names, including lymphadenopathy-associated virus (LAV), 1 , 2 immunodeficiency-associated virus (IDAV), 3 human T-cell lymph...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 313; no. 25; pp. 1586 - 1590
Main Authors Francis, Donald P, Petricciani, John C
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 19.12.1985
Subjects
Acquired Immune Deficiency Syndrome
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - prevention & control
AIDS/HIV
Animals
Antibodies, Viral - immunology
Biological and medical sciences
Deltaretrovirus - genetics
Deltaretrovirus - immunology
DNA, Recombinant
Human Experimentation
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Mutation
Population
Retroviridae - immunology
Social Policy
Vaccination
Vaccination - methods
Viral Vaccines - administration & dosage
Viral Vaccines - standards
Infection
Immunopathology
Skin disease
Viral disease
AIDS
Hemopathy
Vaccine
Venereal disease
Immunologic Factors
Immunization
Health Services
Acquired Immunodeficiency Syndrome > prevention and control
Health
Vaccination
Viral Diseases
Biology
Hiv Infections
Delivery Of Health Care
Research Methodology
Immunity
Research And Development
Diseases
Medicine
Economic Factors
Clinical Research
Technology
Preventive Medicine
Physiology
Primary Health Care
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Summary:ACQUIRED immunodeficiency syndrome (AIDS) is a severe disease of the immune system caused by a horizontally transmitted retrovirus. Although this virus has been given several names, including lymphadenopathy-associated virus (LAV), 1 , 2 immunodeficiency-associated virus (IDAV), 3 human T-cell lymphotropic virus Type III (HTLV-III), 4 and AIDS-associated retrovirus (ARV), 5 it is referred to as HTLV-III/LAV in this discussion. This virus preferentially infects lymphocytes of the T helper subset and destroys them, leaving the host unable to cope with a variety of infectious and neoplastic diseases. 6 The clinical syndrome AIDS is the most severe clinical manifestation of HTLV-III/LAV infection, but there appears to be a wide . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198512193132506