Small intestinal permeability in normal Sudanese subjects: evidence of tropical enteropathy

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 80; no. 2; pp. 204 - 207
• Main Authors: Ukabam, S.O., Homeida, M.M.A., Cooper, B.T.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1986; Royal Society of Tropical Medicine and Hygiene; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Disaccharides - metabolism; England; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intestinal Absorption; Intestinal Diseases - metabolism; Intestine, Small - metabolism; Lactulose - metabolism; Lactulose - urine; Male; Mannitol - metabolism; Mannitol - urine; Medical sciences; Middle Aged; Other diseases. Semiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Sudan; Tropical medicine; England; Sudan; Human; Absorption; Africa; Gut; Sudan; Digestive diseases; Intestinal disease; Permeability
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1016/0035-9203(86)90010-6

Small intestinal permeability to mannitol and lactulose was studied in healthy English and apparently healthy Sudanese subjects to determine whether any differences were apparent. Permeability was assessed by measuring urinary recovery of the test substances after oral ingestion. The mean excretion of lactulose was significantly higher and the mean excretion of mannitol was significantly lower in the Sudanese than in the English subjects. Lactulose to mannitol excretion ratios were significantly higher in the Sudanese. These data demonstrate abnormal intestinal permeability in the Sudanese subjects and indicate the presence of an asymptomatic enteropathy.