Protective Effects of a Novel Lactobacillus brevis Strain with Probiotic Characteristics against Staphylococcus aureus Lipoteichoic Acid-Induced Intestinal Inflammatory Response

Probiotics can effectively modulate host immune responses and prevent gastrointestinal diseases. The objective of this study was to investigate the probiotic characteristics of KU15152 isolated from kimchi and its protective potential against intestinal inflammation induced by lipoteichoic acid (aLT...

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Published inJournal of microbiology and biotechnology Vol. 32; no. 2; pp. 205 - 211
Main Authors Kim, Won-Ju, Hyun, Jun-Hyun, Lee, Na-Kyoung, Paik, Hyun-Dong
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society for Microbiology and Biotechnology 28.02.2022
한국미생물·생명공학회
Subjects
Levilactobacillus brevis
Lipopolysaccharides
Probiotics
Research article
Staphylococcus aureus
Teichoic Acids
생물학
ERK signaling
anti-inflammatory
Probiotics
Akt signaling
HT-29 cell
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Abstract Probiotics can effectively modulate host immune responses and prevent gastrointestinal diseases. The objective of this study was to investigate the probiotic characteristics of KU15152 isolated from kimchi and its protective potential against intestinal inflammation induced by lipoteichoic acid (aLTA). KU15152 exhibited a high survival rate in artificial gastric and bile environments. Additionally, the adhesion capability of the strain to HT-29 cells was higher than that of GG. KU15152 did not produce harmful enzymes, such as β-glucuronidase, indicating that it could be used as a potential probiotic. The anti-inflammatory potential of KU15152 was determined in HT-29 cells. Treatment with KU15152 suppressed the production of interleukin-8 without inducing significant cytotoxicity. The downregulatory effects of KU15152 were involved in the suppression of nuclear factor-kappa B activation mediated by the extracellular signal-regulated kinase and Akt signaling pathways. Collectively, these data suggest that KU15152 can be used in developing therapeutic and prophylactic products to manage and treat aLTA-induced intestinal damage.
AbstractList Probiotics can effectively modulate host immune responses and prevent gastrointestinal diseases. The objective of this study was to investigate the probiotic characteristics of Lactobacillus brevis KU15152 isolated from kimchi and its protective potential against intestinal inflammation induced by Staphylococcus aureus lipoteichoic acid (aLTA). L. brevis KU15152 exhibited a high survival rate in artificial gastric and bile environments. Additionally, the adhesion capability of the strain to HT-29 cells was higher than that of L. rhamnosus GG. L. brevis KU15152 did not produce harmful enzymes, such as β-glucuronidase, indicating that it could be used as a potential probiotic. The antiinflammatory potential of L. brevis KU15152 was determined in HT-29 cells. Treatment with L. brevis KU15152 suppressed the production of interleukin-8 without inducing significant cytotoxicity. The downregulatory effects of L. brevis KU15152 were involved in the suppression of nuclear factorkappa B activation mediated by the extracellular signal-regulated kinase and Akt signaling pathways. Collectively, these data suggest that L. brevis KU15152 can be used in developing therapeutic and prophylactic products to manage and treat aLTA-induced intestinal damage. KCI Citation Count: 0
Probiotics can effectively modulate host immune responses and prevent gastrointestinal diseases. The objective of this study was to investigate the probiotic characteristics of Lactobacillus brevis KU15152 isolated from kimchi and its protective potential against intestinal inflammation induced by Staphylococcus aureus lipoteichoic acid (aLTA). L. brevis KU15152 exhibited a high survival rate in artificial gastric and bile environments. Additionally, the adhesion capability of the strain to HT-29 cells was higher than that of L. rhamnosus GG. L. brevis KU15152 did not produce harmful enzymes, such as β-glucuronidase, indicating that it could be used as a potential probiotic. The anti-inflammatory potential of L. brevis KU15152 was determined in HT-29 cells. Treatment with L. brevis KU15152 suppressed the production of interleukin-8 without inducing significant cytotoxicity. The downregulatory effects of L. brevis KU15152 were involved in the suppression of nuclear factor-kappa B activation mediated by the extracellular signal-regulated kinase and Akt signaling pathways. Collectively, these data suggest that L. brevis KU15152 can be used in developing therapeutic and prophylactic products to manage and treat aLTA-induced intestinal damage.
Probiotics can effectively modulate host immune responses and prevent gastrointestinal diseases. The objective of this study was to investigate the probiotic characteristics of KU15152 isolated from kimchi and its protective potential against intestinal inflammation induced by lipoteichoic acid (aLTA). KU15152 exhibited a high survival rate in artificial gastric and bile environments. Additionally, the adhesion capability of the strain to HT-29 cells was higher than that of GG. KU15152 did not produce harmful enzymes, such as β-glucuronidase, indicating that it could be used as a potential probiotic. The anti-inflammatory potential of KU15152 was determined in HT-29 cells. Treatment with KU15152 suppressed the production of interleukin-8 without inducing significant cytotoxicity. The downregulatory effects of KU15152 were involved in the suppression of nuclear factor-kappa B activation mediated by the extracellular signal-regulated kinase and Akt signaling pathways. Collectively, these data suggest that KU15152 can be used in developing therapeutic and prophylactic products to manage and treat aLTA-induced intestinal damage.
Author Hyun, Jun-Hyun
Paik, Hyun-Dong
Lee, Na-Kyoung
Kim, Won-Ju
AuthorAffiliation Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea
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DocumentTitleAlternate Protective Effects of a Novel Lactobacillus brevis Strain with Probiotic Characteristics against Staphylococcus aureus Lipoteichoic Acid-Induced Intestinal Inflammatory Response
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Keywords ERK signaling
anti-inflammatory
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Akt signaling
HT-29 cell
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SubjectTerms Levilactobacillus brevis
Lipopolysaccharides
Probiotics
Research article
Staphylococcus aureus
Teichoic Acids
생물학
Title Protective Effects of a Novel Lactobacillus brevis Strain with Probiotic Characteristics against Staphylococcus aureus Lipoteichoic Acid-Induced Intestinal Inflammatory Response
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