New approach on trace analysis of triclosan in personal care products, biological and environmental matrices

• Published in: Talanta (Oxford) Vol. 74; no. 5; pp. 1498 - 1504
• Main Authors: Silva, Ana Rita M., Nogueira, J.M.F.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.02.2008; Oxford Elsevier
• Subjects: Analysis methods; Analytical chemistry; Anti-Infective Agents, Local - analysis; Applied sciences; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, High Pressure Liquid - methods; Commercial toothpaste; Compliance; Consumer products; Cosmetics - analysis; Desorption; Environmental Pollutants - analysis; Exact sciences and technology; Global environmental pollution; High performance liquid chromatography; Liquid chromatography; Natural water pollution; Other chromatographic methods; Pollution; Q1; Reproducibility of Results; Saliva; Solvents; Stir bar sorptive extraction; Triclosan; Triclosan - analysis; Wastewater; Water Pollutants, Chemical - analysis; Water sampling; Water treatment and pollution; Triclosan; Stir bar sorptive extraction; Wastewater; Saliva; High performance liquid chromatography; Commercial toothpaste; Performance evaluation; Standard addition method; Chemical analysis; Octanol; HPLC chromatography; Partition coefficient; Selectivity; Solvent extraction; Waste water; Chemical enrichment; Accuracy; Efficiency; Detection limit; Diode array; Trace analysis; Toothpaste; Liquid chromatography; Desorption; Repeatability; Sensitivity; Acetonitrile; Environment
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2007.09.040

Stir bar sorptive extraction and liquid desorption followed by high performance liquid chromatography with diode array detection (SBSE-LD-LC-DAD) is proposed for the determination of triclosan in personal care products, biological and environmental matrices, which is included in the priority lists, set by several international regulatory organizations. Instrumental conditions and experimental parameters that affecting SBSE-LD efficiency are fully discussed. Throughout systematic assays on 25 mL water samples spiked at the 10.0 μg L −1 level, it had been established that stir bars coated with 126 μL of polydimethylsiloxane, an equilibrium time of 1 h (1000 rpm) and acetonitrile under sonification (60 min) as back-extraction solvent, allowed the best analytical performance to determine triclosan in water matrices. From the data obtained, good recovery and remarkable repeatability were attained, providing experimental average yields (78.5 ± 2.2%), although slightly lower than the theoretical equilibrium (99.7%) described by the octanol–water partition coefficients ( K PDMS/W < K O/W). The analytical performance proved suitable precision (<3.6%), convenient detection limits (0.1 μg L −1) and excellent linear dynamic range ( r 2 > 0.9992) from 0.4 to 108.0 μg L −1. The application of the present method to determine triclosan in real matrices such as commercial toothpaste, saliva and urban wastewater samples, allowed appropriate selectivity, high sensitivity and accuracy using the standard addition methodology. The proposed method showed to be feasible and sensitive with a low-sample volume requirement to monitor triclosan in personal care products, biological and environmental matrices at the trace level, in compliance with international regulatory directives.