Disrupted balance: The impact of apheresis on calcium and magnesium metabolism

Apheresis procedures rely on citrate anticoagulation, which can significantly disrupt calcium and magnesium homeostasis. This review outlines the physiological roles and regulation of these essential minerals and explores how citrate-induced binding during apheresis may lead to hypocalcemia and hypo...

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Bibliographic Details
Published inTransfusion and apheresis science Vol. 64; no. 3; p. 104141
Main Authors Valentino, Gustav, Triyono, Teguh, Vrielink, Hans
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2025
Subjects
Apheresis
Blood Component Removal - adverse effects
Blood Component Removal - methods
Calcium
Calcium - metabolism
Citrate
Electrolyte Balance
Hematology, Oncology, and Palliative Medicine
Humans
Hypocalcemia
Hypocalcemia - etiology
Hypomagnesemia
Magnesium
Magnesium - metabolism
Calcium
Apheresis
Citrate
Electrolyte Balance
Magnesium
Hypocalcemia
Hypomagnesemia
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ISSN1473-0502
DOI10.1016/j.transci.2025.104141

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Summary:Apheresis procedures rely on citrate anticoagulation, which can significantly disrupt calcium and magnesium homeostasis. This review outlines the physiological roles and regulation of these essential minerals and explores how citrate-induced binding during apheresis may lead to hypocalcemia and hypomagnesemia. It also summarizes current understanding of the clinical impact and management strategies for maintaining electrolyte balance in patients undergoing apheresis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1473-0502
DOI:10.1016/j.transci.2025.104141