Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 65; pp. 191 - 201
• Main Authors: Sung, Hyunsin H., Sinclair, Andrew J., Huynh, Kevin, Smith, Alexander T., Mellett, Natalie A., Meikle, Peter J., Su, Xiao Q.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019; Elsevier Limited
• Subjects: Chromatography; Crossovers; DHA; Docosahexaenoic acid; Eicosapentaenoic acid; EPA; Euphausiacea; Fatty acids; Fish oil; Fish oils; Ionization; Krill; Krill oil; Lipids; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Metabolism; Oils & fats; Olive oil; Phospholipids; Polyunsaturated fatty acids; Postprandial lipidomic response; Randomization; Seafood; Species; Triacylglycerol; Triacylglycerol; EPA; Krill oil; Postprandial lipidomic response; Phospholipids; DHA; Fish oil
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2019.03.021

•Postprandial lipidomic response to krill oil and fish oil supplementations.•The most noticeable differences are in diacyl-phospholipids and ether-phospholipids.•Krill oil supplementation increased concentrations of five lipid classes and subclasses.•Significant differences were found in 27 molecular species between the two supplementations.•EPA and DHA from krill oil were partitioned toward phospholipid molecular species.•EPA and DHA from fish oil were partitioned toward neutral lipids molecular species. There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 polyunsaturated fatty acids into blood lipid fractions than fish oil (FO). This study examined the postprandial plasma lipidomic responses to KO supplementation compared with FO supplementation in healthy women. Ten women (aged 18–45 y) consumed a high-fat (15 g of olive oil) breakfast, supplemented with 5 g of KO or FO in a randomized crossover study with a minimum 7-d washout period between the supplementations. Plasma samples collected at the fasting state and at 3 and 5 h postprandially were analyzed using liquid chromatography electrospray ionization–tandem mass spectrometry. After the supplementations, 5 out of 34 lipid classes or subclasses had significantly greater concentrations from KO compared with FO. There were 27 molecular species including 5 ether-phospholipid species, out of a total of 701, which had significant differences between supplementations in the postprandial period. Eicosapentaenoic acid and docosahexaenoic acid from KO were preferentially partitioned toward phospholipid molecular species, whereas eicosapentaenoic acid and docosahexaenoic acid from FO were preferentially partitioned toward neutral lipids.