Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[b]thiophenamines
A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regios...
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| Published in | Molecules (Basel, Switzerland) Vol. 28; no. 23; p. 7738 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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MDPI AG
01.11.2023
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| Abstract | A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields. |
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| AbstractList | A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields. A series of benzofuran and benzo[ ]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields. |
| Audience | Academic |
| Author | Yang, Bingchuan Lv, Xueyan Ding, Chengcheng Huang, Xianqiang Yuan, Dong Liu, Ran Lv, Lili Gu, Ziyi Li, Chenglong |
| Author_xml | – sequence: 1 givenname: Ran surname: Liu fullname: Liu, Ran – sequence: 2 givenname: Lili surname: Lv fullname: Lv, Lili – sequence: 3 givenname: Bingchuan surname: Yang fullname: Yang, Bingchuan – sequence: 4 givenname: Ziyi surname: Gu fullname: Gu, Ziyi – sequence: 5 givenname: Chenglong surname: Li fullname: Li, Chenglong – sequence: 6 givenname: Xueyan surname: Lv fullname: Lv, Xueyan – sequence: 7 givenname: Chengcheng surname: Ding fullname: Ding, Chengcheng – sequence: 8 givenname: Xianqiang surname: Huang fullname: Huang, Xianqiang – sequence: 9 givenname: Dong orcidid: 0000-0001-6649-4240 surname: Yuan fullname: Yuan, Dong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38067468$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Anti-arrhythmia drugs benzo[b]thiophenamines benzofuranamines C-C coupling Chromatography one-pot synthesis Palladium Solvents transition metal-free |
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| Title | Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[b]thiophenamines |
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