Transition-Metal-Free One-Pot Synthesis of Fused Benzofuranamines and Benzo[b]thiophenamines

A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regios...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 23; p. 7738
Main Authors Liu, Ran, Lv, Lili, Yang, Bingchuan, Gu, Ziyi, Li, Chenglong, Lv, Xueyan, Ding, Chengcheng, Huang, Xianqiang, Yuan, Dong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.11.2023
Subjects
Anti-arrhythmia drugs
benzo[b]thiophenamines
benzofuranamines
C-C coupling
Chromatography
one-pot synthesis
Palladium
Solvents
transition metal-free
C-C coupling
benzo[b]thiophenamines
benzofuranamines
one-pot synthesis
transition metal-free
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Summary:A series of benzofuran and benzo[b]thiophen derivatives was synthesized via a transition-metal-free one-pot process at room temperature. This one-pot protocol enables the synthesis of compounds with high reaction efficiency, mild conditions, simple methods, and a wide-ranging substrate scope. Regioselective five-membered heterocycles were constructed in good-to-excellent yields.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28237738