Comparison of the second consensus statement with the movement disorder society criteria for multiple system atrophy: A single-center analysis

• Published in: Parkinsonism & related disorders Vol. 106; p. 105242
• Main Authors: Sun, Yunchuang, Sun, Wei, Wei, Luhua, Li, Fan, Jiang, Yanyan, Zhai, Fei, Luan, Mingyue, Chen, Jing, Wang, Zhaoxia
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2023
• Subjects: Diagnostic criteria; Humans; Movement disorder society; Multiple system atrophy; Multiple System Atrophy - diagnosis; Retrospective Studies; Second consensus statement; Movement disorder society; Multiple system atrophy; Diagnostic criteria; Second consensus statement
• ISSN: 1353-8020; 1873-5126
• DOI: 10.1016/j.parkreldis.2022.105242

This study aimed at comparing the differences between the second consensus statement and Movement Disorder Society (MDS) criteria for Multiple System Atrophy (MSA) in a single Chinese cohort. We retrospectively reviewed 73 patients with MSA over the past five years. They were categorized as patients with probable and possible MSA according to the second consensus statement in addition to clinically established and clinically probable MSA according to the MDS criteria. The core clinical, supportive clinical, and imaging features were analyzed and compared between the two MSA subtypes. A total of 40 patients with MSA-P and 33 patients with MSA-C were included in this study. Approximately 78.7% of the category of probable patients in the second consensus statement can be categorized as clinically established MSA in the MDS criteria and five patients with non-supporting features in the second consensus statement criteria can be diagnosed as clinically probable MSA in the MDS criteria. “Rapid progression” and “moderate to severe postural instability” within three years of motor onset dominated among the supportive features. Approximately 78.9% of patients possessed at least one imaging marker with predominant signal decrease of putamen on iron-sensitive sequences (38.0% of patients). Twenty-two patients could not be diagnosed as clinically established MSA mainly due to the lack of supportive or imaging features. A high degree of agreement was noticed between the two criteria sets. The supportive and imaging features played important role in the diagnosis of MSA and affected the diagnostic level in the current criteria. [Display omitted] •MSA is accompanied with parkinsonism or cerebellar ataxia.•We compared the second consensus statement with the new MDS criteria for MSA.•High consistency was noted between the second consensus statement and MDS criteria.•Supportive and imaging features are important for diagnosing MSA.