Modeling of Retinal Degeneration

• Published in: Bulletin of experimental biology and medicine Vol. 171; no. 2; pp. 286 - 291
• Main Authors: Suetov, A. A., Boiko, E. V., Alekperov, S. I., Odinokaya, M. A., Kostina, A. A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2021; Springer; Springer Nature B.V
• Subjects: Adaptation, Ocular - radiation effects; Analysis; Animals; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell Biology; Degenerative diseases; Disease Models, Animal; Epithelium; Homeopathy; Internal Medicine; Laboratory Medicine; Light; Macular degeneration; Male; Materia medica and therapeutics; Methods; Pathology; Photoreceptor Cells - pathology; Photoreceptor Cells - radiation effects; Physiological aspects; Rabbits; Retina; Retina - pathology; Retina - radiation effects; Retinal degeneration; Retinal Degeneration - pathology; Retinal pigment epithelium; Structure-function relationships; Therapeutics; experimental model; retina; degeneration; rabbit
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05213-4

We developed a model of retinal degeneration in rabbits based on exposure to light with a wavelength of 405 nm. This model allows reproducing structural and functional disorders in the central parts of the retina, including primarily degeneration of the outer layers of the retina (retinal pigment epithelium and layer of photoreceptor cells), and is designed to study the mechanisms of formation, progression and effectiveness of new drugs and methods of treatment of degenerative diseases of the retina.