The ages of the cancer-associated genes

In the accompanying manuscript (Litman and Stein, 2018) we list the ages of all the protein-coding genes and of many of the noncoding genes of the human genome. The present manuscript uses those results to derive the ages of the genes on the COSMIC list of somatic mutations in cancer. The lymphoma-a...

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Bibliographic Details
Published inSeminars in oncology Vol. 46; no. 1; pp. 10 - 18
Main Author Stein, Wilfred D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2019
Subjects
Cosmic genes
Gene ages
Undrugged genes
Undrugged genes
Cosmic genes
Gene ages
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Summary:In the accompanying manuscript (Litman and Stein, 2018) we list the ages of all the protein-coding genes and of many of the noncoding genes of the human genome. The present manuscript uses those results to derive the ages of the genes on the COSMIC list of somatic mutations in cancer. The lymphoma-associated genes in the COSMIC list are younger than the sarcoma-associated or the carcinoma-associated genes, or the genes shared by lymphomas and carcinomas. Genes that accreted to the evolving genome with the appearance of the fish are major contributors to the sarcoma-, lymphoma-, or carcinoma-associated gene sets, but it is genes accreted during the development of multicellularity that contribute most to the genes common to the classes. Genes arising with the evolution of the fish are also dominant in a list of noncoding genes associated with cancer. A list is provided of the COSMIC genes which have not yet been reported as drug targets.
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ISSN:0093-7754
1532-8708
DOI:10.1053/j.seminoncol.2018.11.001