Helicobacter Pylori associated global gastric cancer burden

Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5....

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Published inFrontiers in bioscience Vol. 14; no. 14; pp. 1490 - 1504
Main Author Mbulaiteye, Sam, M.
Format Journal Article
LanguageEnglish
Published Singapore 2009
Subjects
Global Health
Helicobacter pylori - pathogenicity
Humans
Incidence
Lymphoma, B-Cell, Marginal Zone - epidemiology
Lymphoma, B-Cell, Marginal Zone - microbiology
Lymphoma, B-Cell, Marginal Zone - prevention & control
Risk Factors
Stomach Neoplasms - epidemiology
Stomach Neoplasms - microbiology
Stomach Neoplasms - prevention & control
Virulence
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Summary:Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers.
ISSN:1093-9946
1093-4715
2768-6698
DOI:10.2741/3320