Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification

Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are...

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Bibliographic Details
Published inScience translational medicine Vol. 1; no. 7; p. 7ps8
Main Authors Ioannidis, John P A, Loy, En Yun, Poulton, Richie, Chia, Kee Seng
Format Journal Article
LanguageEnglish
Published United States 18.11.2009
Subjects
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Models, Genetic
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Summary:Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.
ISSN:1946-6242
DOI:10.1126/scitranslmed.3000247