Clinical Safety and Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Transplantation in Sensorineural Hearing Loss Patients

Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral...

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Bibliographic Details
Published inJournal of audiology & otology Vol. 22; no. 2; pp. 105 - 109
Main Authors Lee, Ho Seok, Kim, Woo Jin, Gong, Ji Sun, Park, Kyoung Ho
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Audiological Society and Korean Otological Society 01.04.2018
대한청각학회
Subjects
Case Report
이비인후과학
Electrical stimulation
Sensorineural hearing loss
Bone marrow derived mesenchymal stem cell
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ISSN2384-1621
2384-1710
DOI10.7874/jao.2017.00150

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Summary:Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing.
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ISSN:2384-1621
2384-1710
DOI:10.7874/jao.2017.00150