Extracellular Matrix Components of Rat Lungs after Direct and Indirect Lung Injury

• Published in: Bulletin of experimental biology and medicine Vol. 172; no. 4; pp. 407 - 409
• Main Authors: Samoilova, Е. V., Chepurnova, D. A., Fesenko, A. G., Korotaeva, А. А.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2022; Springer; Springer Nature B.V
• Subjects: Acute respiratory distress syndrome; Animals; Biomedical and Life Sciences; Biomedicine; Cell Biology; Collagen; Collagen (type III); Collagen (type IV); Collagen - metabolism; Extracellular matrix; Extracellular Matrix - metabolism; Fibronectin; Fibronectins; Fibronectins - metabolism; Gene expression; Genes; Internal Medicine; Intravenous administration; Laboratory Medicine; Lipopolysaccharides; Lung - metabolism; Lung Injury - chemically induced; Lung Injury - genetics; Lung Injury - metabolism; Lungs; Pathogens; Pathology; Rats; Trachea; collagens; acute lung injury; extracellular matrix; gene expression
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05403-8

We studied the effects of direct intratracheal and indirect intravenous administration of pathogen on the concentrations of types I, III, and IV collagens and fibronectin and expression of the corresponding genes at the early stages of LPS-induced lung injury. Direct and indirect administration of LPS increased the level of type III collagen and decreased the expression of genes encoding types I and III collagens. Expression of type IV collagen remained unchanged. Considerable decrease in fibronectin gene expression was observed after direct LPS administration. Thus, changes in the extracellular matrix of the lungs at the early stages of acute lung injury differ depending on the way of pathogen administration.