Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

• Published in: Molecular neurobiology Vol. 59; no. 7; pp. 4384 - 4404
• Main Authors: Islam, Fahadul, Nafady, Mohamed H., Islam, Md. Rezaul, Saha, Susmita, Rashid, Salma, Akter, Aklima, Or-Rashid, Md. Harun, Akhtar, Muhammad Furqan, Perveen, Asma, Md. Ashraf, Ghulam, Rahman, Md. Habibur, Hussein Sweilam, Sherouk
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2022; Springer Nature B.V
• Subjects: Alzheimer's disease; Antioxidants; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognition; Cognitive ability; Dementia disorders; Disease; Hippocampus; Inflammation; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurogenesis; Neurology; Neuroprotection; Neurosciences; Oxidative stress; Peptides; Phosphorylation; Resveratrol; SIRT1 protein; Tau protein; Toxicity; Oxidative stress; Neuroinflammation; Autophagy induction; Alzheimer’s disease; SIRT1; Resveratrol
• ISSN: 0893-7648; 1559-1182
• DOI: 10.1007/s12035-022-02859-7

Alzheimer’s disease (AD) is the most common cause of dementia and cognitive impairment; yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative stress, and inflammation in AD is pathogenic. The accumulation of amyloid-beta (Aβ) peptides in these neurocognitive areas is a significant characteristic of the disease. Therefore, inhibiting Aβ peptide aggregation has been proposed as the critical therapeutic approach for AD treatment. Resveratrol has been demonstrated in multiple studies to have a neuroprotective, anti-inflammatory, and antioxidant characteristic and the ability to minimize Aβ peptides aggregation and toxicity in the hippocampus of Alzheimer’s patients, stimulating neurogenesis and inhibiting hippocampal degeneration. Furthermore, resveratrol’s antioxidant effect promotes neuronal development by activating the silent information regulator-1 (SIRT1), which can protect against the detrimental effects of oxidative stress. Resveratrol-induced SIRT1 activation is becoming more crucial in developing novel therapeutic options for AD and other diseases that have neurodegenerative characteristics. This review highlighted a better knowledge of resveratrol’s mechanism of action and its promising therapeutic efficacy in treating AD. We also highlighted the therapeutic potential of resveratrol as an AD therapeutic agent, which is effective against neurodegenerative disorders.