Selective detection of saxitoxin over tetrodotoxin using acridinylmethyl crown ether chemosensor

At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. The...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 45; no. 6; pp. 783 - 787
Main Authors Gawley, Robert E., Shanmugasundaram, Muthian, Thorne, John B., Tarkka, Richard M.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.05.2005
Elsevier Science
Subjects
Animal poisons toxicology. Antivenoms
Biological and medical sciences
Biosensing Techniques - methods
Chemistry Techniques, Analytical - methods
Chromatography, Gel
Coumarins - chemistry
Crown Ethers - chemistry
Fluorescence sensor
Hydrogen-Ion Concentration
Medical sciences
Protein Binding
PSP
Saxitoxin
Saxitoxin - analysis
Saxitoxin - chemistry
Tetrodotoxin
Tetrodotoxin - analysis
Tetrodotoxin - chemistry
Toxicology
Tetrodotoxin
Saxitoxin
Fluorescence sensor
PSP
Chemical analysis
Analysis method
Fluorescence
Paralytic shellfish poisoning
Detection
Quantitative analysis
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Summary:At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. These sensors are selective for the detection of saxitoxin over tetrodotoxin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2005.01.019