Neurodevelopmental Delay After the Neonatal Repair of Coarctation and Arch Obstruction

• Published in: The Annals of thoracic surgery Vol. 108; no. 5; pp. 1416 - 1422
• Main Authors: Simon, Bartholomew V., Swartz, Michael F., Orie, Jennifer M., Adams, Heather R., Seltzer, Laurie E., Angona, Ron E., Atallah-Yunes, Nader H., Alfieris, George M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2019
• Subjects: Aorta, Thoracic - surgery; Aortic Coarctation - surgery; Arterial Occlusive Diseases - surgery; Developmental Disabilities - epidemiology; Female; Humans; Infant, Newborn; Male; Postoperative Complications - epidemiology; Prospective Studies; Vascular Surgical Procedures; AR; Vineland-III; CPB; Iso CoA; MRI; DHCA; CHD; RCP; NDD
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/j.athoracsur.2019.04.088

Although single ventricle physiology and cyanosis are known risk factors for neurodevelopmental delay (NDD), the impacts of isolated coarctation (Iso CoA) repair or arch reconstruction (AR) are less understood. The Vineland Adaptive Behavior Scales, third edition, prospectively evaluated children without a genetic syndrome. An overall composite score, normalized to age and sex, was generated from individual domain scores. NDD was defined as a composite or domain score at least 1 SD less than the established mean. Iso CoA was repaired using a left thoracotomy, whereas AR was performed using a sternotomy and cardiopulmonary bypass. Children with a structurally normal heart and without previous surgery were used as control patients. Of 60 children, 50 required neonatal repair (12 for Iso CoA, 38 for AR), and 10 were control patients. From the entire cohort of children who required neonatal coarctation repair (Iso CoA + AR) composite (93.9 ± 15.9 vs 105.0 ± 7.4; P = .004) and all domain scores were significantly lower than control patients. NDD was present in 25 of 50 children after repair and in 0 of 10 control patients (P = .003). Similarly, the prevalence of NDD was significantly greater after Iso CoA repair (58.3% vs 0%; P = .005) and AR (47.3% vs 0%; P = .007) than in the control population, but no significant difference was found between the Iso CoA and AR groups (P = .74). In this small cohort, half of the neonates who required either Iso CoA repair or AR exhibit NDD at an intermediate-term follow-up.