Simultaneous irradiation and imaging of blood vessels during pulsed laser delivery
Background and Objective Simultaneous irradiation and viewing of 10–120 μm cutaneous blood vessels were performed to investigate the effects of 2‐μs 577‐nm dye laser pulses. Study Design/Materials and Methods A modified scanning laser confocal microscope recorded vessel response to different radiant...
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Published in | Lasers in surgery and medicine Vol. 24; no. 3; pp. 236 - 243 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
1999
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Background and Objective
Simultaneous irradiation and viewing of 10–120 μm cutaneous blood vessels were performed to investigate the effects of 2‐μs 577‐nm dye laser pulses.
Study Design/Materials and Methods
A modified scanning laser confocal microscope recorded vessel response to different radiant exposures (J/cm2). Probit analysis determined the 50% probability (“threshold”) radiant exposure necessary to cause embolized or partly occluding coagula, coagula causing complete blood flow stoppage, and hemorrhage.
Results
A statistically significant difference in the threshold radiant exposure existed for each damage category for blood vessels 10–30 μm in diameter, but not for larger vessels. For vessels over 60 μm, complete flow stoppage was unattainable; increasing laser pulse energy produced hemorrhage. In larger vessels, coagula often were attached to the superficial vessel wall while blood flowed underneath. Monte Carlo optical and finite difference thermal modeling confirmed experimental results.
Conclusion
These results provide insight into the role of pulse duration and vessel diameter in the outcome of pulsed dye laser irradiation. Lasers Surg. Med. 24:236–243, 1999. © 1999 Wiley‐Liss, Inc. |
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Bibliography: | istex:64BADD21A13825E4BCE9B5AC96DC997ED64B1419 ArticleID:LSM9 Office of Naval Research Free Electron Laser Biomedical Science Program - No. N00014-91-J-1564 ark:/67375/WNG-NLF1Z6NZ-J Albert and Clemmie Caster Foundation ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0196-8092 1096-9101 |
DOI: | 10.1002/(SICI)1096-9101(1999)24:3<236::AID-LSM9>3.0.CO;2-I |