REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL GROWTH I. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

• Published in: Journal of antibiotics Vol. 45; no. 9; pp. 1409 - 1413
• Main Authors: TAKAHASHI, HIDETOSHI, OSADA, HIROYUKI, KOSHINO, HIROYUKI, KUDO, TAKUJI, AMANO, SHUICHI, SHIMIZU, SHINJI, YOSHIHAMA, MAKOTO, ISONO, KIYOSHI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1992; Japan Antibiotics Research Association
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Cell Division - drug effects; Chemotherapic agents; Epidermal Growth Factor - antagonists & inhibitors; Fundamental and applied biological sciences. Psychology; Mice; Microbiology; Pyrans - chemistry; Pyrans - isolation & purification; Pyrans - pharmacology; Spiro Compounds - chemistry; Spiro Compounds - isolation & purification; Spiro Compounds - pharmacology; Streptomyces - chemistry; Cell proliferation; Streptomycetaceae; Rodentia; Streptomyces; Actinomycetales; Vertebrata; Antibiotic; Mammalia; Epidermal growth factor; Mouse; Animal; Bacteria; Isolation; Actinomycetes; Inhibitor; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.45.1409

New antibiotics named reveromycins A, B, C and D were isolated as inhibitors of mitogenic activity induced by epidermal growth factor (EGF) in a mouse epidermal keratinocyte. Reveromycins were produced by a soil actinomycete (strain SN-593) which belongs to the genus Streptomyces.