The genetic source tracking of human urinary exosomes

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 118; no. 43; pp. 1 - 3
Main Authors Zhu, Qingfu, Cheng, Liming, Deng, Chunyu, Huang, Liu, Li, Jiaoyuan, Wang, Yong, Li, Meng, Yang, Qinsi, Dong, Xianjun, Su, Jianzhong, Lee, Luke P., Liu, Fei
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 26.10.2021
SeriesBrief Report
Subjects
Biological Sciences
Biomarkers
Biopsy
Body fluids
BRIEF REPORTS
Cancer
Dendritic cells
Endothelial cells
Exosomes
Exosomes - metabolism
Gene sequencing
Genes
Genetic relationship
Humans
Liquid Biopsy
Monocytes
Neoplasms - metabolism
Neoplasms - pathology
Precision medicine
Tracking
Urine
RNA sequencing
cancer diagnosis
biomarker discovery
exosome origin
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Summary:The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.
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Edited by James A. Wells, University of California, San Francisco, CA, and approved August 30, 2021 (received for review May 20, 2021)
1Q.Z., L.C., and C.D. contributed equally to this work.
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.2108876118