Relationship between Hypogonadal Symptoms, Sexual Dysfunction and Chronic Prostatitis in Middle-Aged Men by Self-Reported Questionnaires, even without Biochemical Testosterone Deficiency

• Published in: The world journal of men's health Vol. 38; no. 2; pp. 243 - 249
• Main Authors: Lee, Min Ho, Seo, Deok Ha, Lee, Chun Woo, Choi, Jae Hwi, Jeh, Seong Uk, Lee, Sin Woo, Choi, See Min, Hwa, Jeong Seok, Hyun, Jae Seog, Chung, Ky Hyun, Kam, Sung Chul
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Sexual Medicine and Andrology 01.04.2020; 대한남성과학회
• Subjects: Androgens; Body mass index; Cardiovascular disease; Diabetes; Erectile dysfunction; Hypertension; hypogonadism; Middle age; Original; Pain; premature ejaculation; Prostate; prostatitis; Questionnaires; Self report; Sexual disorders; Testosterone; Ultrasonic imaging; 비뇨기과학; Premature ejaculation; Erectile dysfunction; Prostatitis; Hypogonadism; Questionnaires
• ISSN: 2287-4208; 2287-4690
• DOI: 10.5534/wjmh.190117

To investigate the association of erectile dysfunction (ED), premature ejaculation (PE), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men with late-onset hypogonadism (LOH). We reviewed the data of 408 enrolled men between January 2014 and January 2019. All participants completed the Androgen Deficiency in the Aging Male (ADAM), international index of erectile function-5 (IIEF-5), National Institutes of Health chronic prostatitis symptom index (NIH-CPSI), and premature ejaculation diagnostic tool (PEDT) questionnaires. Participants were divided by ADAM positive (ADAM+: Group 1) and ADAM negative (ADAM-: Group 2). Total of 289 subjects were in Group 1 and 119 were in Group 2. The mean age was 53.8±7.8 years. The mean total testosterone was 4.8±1.2 ng/dL and showed no differences between the groups (p=0.839). In Groups 1 and 2, ED (IIEF≤21) was identified in 233 (80.6%) versus 37 (31.1%), respectively (p<0.001). The prevalence of PE (PEDT≥9) was 112 (38.7%) versus 13 (10.9%) in Groups 1 and 2, respectively (p<0.001). However, PE (intravaginal ejaculation latency time<5 minutes) showed no differences between the groups (p=0.863). The incidence of chronic prostatitis (NIH-CPSI pain score≥4) showed significant differences with 49 (17.0%) versus 8 (6.7%) in Groups 1 and 2, respectively (p=0.007). IIEF-5 total score showed the significantly highest negative correlation (r=-0.313, p<0.001). Those who complained of LOH symptoms and positive results in the ADAM questionnaire need to be assessed concurrently with the above questionnaires. This could aid useful to detect of ED, PE, and chronic prostatitis co-occurrence.