Higher C-peptide levels are associated with regional cortical thinning in 1093 cognitively normal subjects

Background and purpose Recent studies have demonstrated an association between increased insulin secretion and cognitive impairment. However, there is no previous study that directly evaluates the association between increased insulin secretion and cortical thickness to our knowledge. Therefore, our...

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Published inEuropean journal of neurology Vol. 21; no. 10; pp. 1318 - e81
Main Authors Yoon, C. W., Kang, M., Shin, H. Y., Jeon, S., Yang, J.-J., Kim, S. T., Noh, Y., Kim, G. H., Kim, H. J., Kim, Y. J., Kim, J.-H., Cho, H., Ye, B. S., Lee, J. M., Choi, S. H., Im, K., Moon, H.-S., Na, D. L., Seo, S. W.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.10.2014
John Wiley & Sons, Inc
Subjects
Aged
C-peptide
C-Peptide - blood
Cerebral Cortex - pathology
cortical thinning
Female
Humans
Hyperinsulinism - blood
insulin
Magnetic Resonance Imaging
Male
Medical research
Middle Aged
NMR
Nuclear magnetic resonance
Peptides
insulin
C-peptide
cortical thinning
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Summary:Background and purpose Recent studies have demonstrated an association between increased insulin secretion and cognitive impairment. However, there is no previous study that directly evaluates the association between increased insulin secretion and cortical thickness to our knowledge. Therefore, our aim was to evaluate the effect of hyperinsulinemia, as measured by C‐peptide level, on cortical thickness in a large sample of cognitively normal individuals. Methods Cortical thickness was measured in 1093 patients who visited the Samsung Medical Health Promotion Center and underwent brain magnetic resonance imaging (MRI) and a blood test to measure C‐peptide concentration. Automated surface‐based analyses of the MRI data were used to measure cortical thickness. C‐peptide levels were divided into quartiles for comparison. Patients in the first to third quartiles were used as the reference category. Results Patients in the highest quartile group (Q4) of C‐peptide levels showed cortical thinning, predominantly in both medial temporal lobes, the right inferior temporal gyrus, both medial prefrontal lobes and the right superior parietal lobule, compared with the lower quartile groups (Q1–Q3) after controlling for age, gender, body mass index, history of hypertension, hyperlipidemia, previous stroke, cardiovascular disease and fasting glucose level. Conclusions A higher C‐peptide level is associated with regional cortical thinning, even in cognitively normal individuals.
Bibliography:ark:/67375/WNG-GDF7MN6W-8
National Research Foundation of Korea (NRF)
Ministry of Science, ICT and Future Planning, Korea - No. 2013K000338
Ministry of Education - No. NRF-2013R1A1A2065365
Samsung Medical Center - No. CRL-108011; No. CRS110-14-1
KOSEF NRL - No. 2011-0028333
Korean Healthcare Technology R&D Project Ministry for Health and Welfare Affairs - No. HI10C2020; No. HIC120713
istex:2CC4774B1C5BB9A02196868C1D180964B75A43C8
Figure S1. Predicted mean global cortical thickness and 95% confidence interval according to C-peptide levels.Figure S2. Scatter plot of mean cortical thickness of areas with significant differences between the lower (Q1-Q3, C-peptide ≤ 2.21 ng/ml) and highest C-peptide quartile groups (Q4, C-peptide > 2.21 ng/ml).Table S1. Characteristic comparisons of subjects who underwent or did not undergo a C-peptide blood test. Table S2. The association between C-peptide and mean cortical thickness of each lobe in individuals without diabetes mellitus. Table S3. The association between C-peptide and mean cortical thickness of each lobe in individuals without obese BMI (≥30 kg/m2). Table S4. The association between C-peptide and mean cortical thickness of each lobe in individuals without history of prior stroke. Table S5. The association between C-peptide and mean cortical thickness of each lobe in men and women. Table S6. The association between continuous C-peptide and mean cortical thickness of each lobe. Table S7. The association between C-peptide and mean cortical thickness of each lobe (after the exclusion of two outliers).
ArticleID:ENE12485
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
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ISSN:1351-5101
1468-1331
DOI:10.1111/ene.12485