Comparative analysis of neurulation: First impressions do not count

The central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems...

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Bibliographic Details
Published inMolecular reproduction and development Vol. 76; no. 10; pp. 954 - 965
Main Authors Harrington, Michael J., Hong, Elim, Brewster, Rachel
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2009
Wiley-Liss
Subjects
Animals
Biological and medical sciences
Early stages. Segmentation. Gastrulation. Neurulation
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Neurulation - physiology
Signal Transduction
Embryonic development
Signal transduction
Vertebrata
Neural tube
Neurulation
Comparative study
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Summary:The central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems. Yet, it remains unclear to what extent neurulation is conserved across vertebrates. This review provides a comparison between modes of neurulation, with a focus on cellular mechanisms. An emerging concept is that cell behaviors reveal similarities between modes of neurulation that cannot be predicted from morphological comparisons. Mol. Reprod. Dev. 76: 954–965, 2009. © 2009 Wiley‐Liss, Inc.
Bibliography:istex:9AC4E44AB0F021831342209542A96BCD9F64CB4C
Michael Harrington and Elim Hong contributed equally to this work.
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ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.21085